Lopatina N G, Ryzhova I V, Dmitrieva L A, Chesnokova E G, Woyke J
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Ross Fiziol Zh Im I M Sechenova. 2000 Oct;86(10):1323-30.
Effects of some drugs on the short-term memory were tested. In kynurenine deficit, mutant snow laranja manifested the same pharmacological profile and 10 to 100-fold enhancement of sensitivity of the NMDA receptors' different sites. The data obtained suggest that the gene controlling the key enzyme activity of the kynurenine pathway of tryptophan metabolism is involved in regulation of the CNS NMDA receptors' functional condition. The kynurenines may be classified as endogenous modulators of the NMDA receptor sensitivity.
