Sándor P S, Afra J, Proietti Cecchini A P, Albert A, Schoenen J
Department of Neurology, CHR Citadelle, University of Liège, Belgium.
Funct Neurol. 2000;15 Suppl 3:68-72.
Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors.
偏头痛患者在发作间期表现出皮质信息处理受损，模式翻转视觉诱发电位（VEP）的习惯化不足，以及听觉皮质诱发电位的强度依赖性增强（IDAP）。这可能是一种遗传特征，因为健康受试者的诱发电位存在某些已知的遗传模式。对40名偏头痛患者（即20对父母及其子女）进行了VEP习惯化和IDAP研究。我们开发了一种基于蒙特卡洛统计的新方法，以选择性地评估垂直家族影响。父母和子女两组均表现出异常的VEP习惯化和IDAP。然而，相关配对之间的相似性远比不相关配对之间的相似性更为明显。通过一种新的统计方法评估，家族影响在确定偏头痛患者的皮质信息处理方面被证明具有高度显著性，从而支持了遗传因素的重要作用。
