1型糖尿病的通气肺功能测试

Ventilatory pulmonary function tests in type 1 diabetes mellitus.

作者信息

Makkar P, Gandhi M, Agrawal R P, Sabir M, Kothari R P

机构信息

Department of Medicine, SP Medical College, Bikaner-334 003.

出版信息

J Assoc Physicians India. 2000 Oct;48(10):962-6.

PMID:11200919

Abstract

OBJECTIVE

To study the ventilatory pulmonary function tests (VPFT) in type one diabetes mellitus and to correlate it with duration, meticulous metabolic control and various complications of diabetes.

METHODOLOGY

Spirometric evaluation of 50 young (15-30 years of age) type one diabetes mellitus patients was done under the case control longitudinal study. After recording baseline parameters patients were subjected to PFT.

OBSERVATIONS

Degree of derangement in VPFTs was directly related to duration and metabolic control of diabetes. VPFT parameters such as FVC, FEV1, PEFR, MEF 75% and MEF 25% showed significant reduction (p = 0.009, = 0.001, = 0.001, = 0.05 respectively). Similarly patients with HbA1c > 10% showed significant reduction in FVC, FEV1, PEFR and MEF 75% (p = 0.001 for each). Diabetic patients with complications particularly peripheral neuropathy and nephropathy had significant reduction in FVC, FEV1 and PEFR (p = 0.001).

CONCLUSION

Spirometric evaluation in type one diabetes mellitus showed varying derangements in the different parameters of VPFTs, suggestive of dominantly restrictive with some obstructive pattern as indicated by significant decline in FVC, PEFR and MEF 75%.

摘要

目的

研究1型糖尿病患者的通气肺功能测试（VPFT），并将其与糖尿病病程、精细代谢控制及各种并发症相关联。

方法

在病例对照纵向研究中，对50名年轻（15 - 30岁）的1型糖尿病患者进行了肺量计评估。记录基线参数后，对患者进行肺功能测试（PFT）。

观察结果

通气肺功能测试的紊乱程度与糖尿病病程和代谢控制直接相关。VPFT参数如用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、呼气峰值流速（PEFR）、75%最大呼气中期流速（MEF 75%）和25%最大呼气中期流速（MEF 25%）均显著降低（p值分别为0.009、0.001、0.001、0.05）。同样，糖化血红蛋白（HbA1c）> 10%的患者FVC、FEV1、PEFR和MEF 75%显著降低（每项p值均为0.001）。患有并发症尤其是周围神经病变和肾病的糖尿病患者FVC、FEV1和PEFR显著降低（p = 0.001）。