Breuninger H
HNO. 1976 Oct;24(10):329-32.
Our knowledge of the effects of drugs on the inner ear is extremely insufficient when compared to their effects on other organs. The role of drugs commonly recommended for therapy of inner ear disorders (such as, procaine, antihistaminics, diuretics, osmotics, corticoids and substances changing blood viscosity) has yet to be clarified since the clinical effects of these pharmaceuticals or vasoactive substances often cannot be confirmed by experimental study. Under present circumstances, the use of definitive therapy to prevent deafness has only limited application--as in thyroid hormone substitution to prevent deafness from cretinism.
与药物对其他器官的作用相比，我们对药物对内耳作用的了解极其不足。常用于治疗内耳疾病的药物（如普鲁卡因、抗组胺药、利尿剂、渗透性药物、皮质类固醇和改变血液粘度的物质）的作用尚未阐明，因为这些药物或血管活性物质的临床效果往往无法通过实验研究得到证实。在目前情况下，使用确定性疗法预防耳聋的应用有限——如用甲状腺激素替代疗法预防呆小症导致的耳聋。
