Qiao H, Noda Y, Kamei H, Nagai T, Furukawa H, Miura H, Kayukawa Y, Ohta T, Nabeshima T
Department of Psychiatry, Nagoya University Graduate School of Medicine, Meijo University, Japan.
Neuroreport. 2001 Jan 22;12(1):11-5. doi: 10.1097/00001756-200101220-00010.
Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SB deficit was observed on repeated treatment with methamphetamine for 14 days. The SB deficit produced by treatment with PCP (10 mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SB in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SB deficit.
苯环己哌啶（PCP）以剂量和时间依赖性方式降低社交行为（SB）。然而，在连续14天用甲基苯丙胺重复治疗后未观察到这种社交行为缺陷。用PCP（10毫克/千克/天）治疗14天产生的社交行为缺陷，在停药后持续28天，给予氯氮平（10毫克/千克/天）7天可使其减轻，而给予氟哌啶醇7天则无效果。在相同治疗剂量下，单独使用氯氮平而非氟哌啶醇可增加生理盐水处理小鼠的社交行为。这些结果表明，所提出的小鼠PCP模型将为测试非典型抗精神病药物对精神分裂症社交功能障碍的有益作用提供一种工具，并有助于我们理解氯氮平改善社交行为缺陷的机制。
