Na H S, Kim H J, Sung B, Back S K, Kim D Y, Kim J S, Hong S K
Neuroscience Research Institute and Department of Physiology, Korea University College of Medicine, Seoul.
Neuroreport. 2001 Jan 22;12(1):175-8. doi: 10.1097/00001756-200101220-00042.
We tested the hypothesis that the decrease in spinal levels of SP and CGRP after peripheral nerve injury is related to neuropathic pain. We compared two groups of rats, both of which were subjected to unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves. One group exhibited well-developed neuropathic signs after the nerve injury, whereas the other group showed poorly developed signs despite the same nerve injury. The decrease in immunoreactivity of CGRP and SP in the S1 dorsal horn (injured segment) was not significantly different between the two groups. These results suggest that the decrease in spinal levels of CGRP and SP after peripheral nerve injury is not related to neuropathic pain.
周围神经损伤后脊髓中P物质（SP）和降钙素基因相关肽（CGRP）水平的降低与神经性疼痛有关。我们比较了两组大鼠，两组均接受S1和S2脊神经之间的单侧尾上干和尾下干横断术。一组在神经损伤后表现出明显的神经性体征，而另一组尽管接受了相同的神经损伤，但其体征表现并不明显。两组之间S1背角（损伤节段）中CGRP和SP的免疫反应性降低并无显著差异。这些结果表明，周围神经损伤后脊髓中CGRP和SP水平的降低与神经性疼痛无关。
