Tsutsumi K, Kusunoki M, Hara T, Okada K, Sakamoto S, Ohnaka M, Nakay Y
Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan.
Biol Pharm Bull. 2001 Jan;24(1):88-91. doi: 10.1248/bpb.24.88.
Exercise decreases plasma total cholesterol and triglycerides, and simultaneously, increases high density lipoprotein (HDL) cholesterol. Furthermore, it has been reported that exercise improves insulin resistance. As a result, exercise is believed to aid in preventing atherosclerosis. However, we do not know whether exercise protects against the development of atherosclerosis in the elderly. The aim of this study was to ascertain whether exercise prevented atherosclerosis in aorta of old rats. Exercise for three months did not affect plasma lipid levels but decreased accumulation of visceral fat and body weight without the reduction of food intake in two year old rats. Exercise also decreased triglycerides in liver and gastrocnemius white muscle. Exercise resulted in an elevation of plasma lipid peroxide (LPO) levels without affecting superoxide dismutase (SOD). Exercise impaired the endothelium-dependent relaxation of the thoracic aorta caused by acetylcholine in old rats. In summary, the results of our study indicate that exercise induces the reduction of visceral fat, body weight and triglyceride contents in tissues in old rats. These results seems to show that exercise improves insulin resistance. However, exercise simultaneously may cause impaired endothelium-dependent relaxation by elevation of LPO in old rats.
运动可降低血浆总胆固醇和甘油三酯水平，同时增加高密度脂蛋白（HDL）胆固醇水平。此外，据报道运动可改善胰岛素抵抗。因此，运动被认为有助于预防动脉粥样硬化。然而，我们尚不清楚运动是否能预防老年人动脉粥样硬化的发展。本研究的目的是确定运动是否能预防老年大鼠主动脉粥样硬化的发生。对两岁大鼠进行三个月的运动，并未影响其血浆脂质水平，但减少了内脏脂肪堆积和体重，且未减少食物摄入量。运动还降低了肝脏和腓肠肌白色肌肉中的甘油三酯水平。运动导致血浆脂质过氧化物（LPO）水平升高，而对超氧化物歧化酶（SOD）无影响。运动损害了老年大鼠胸主动脉对乙酰胆碱的内皮依赖性舒张功能。总之，我们的研究结果表明，运动可导致老年大鼠内脏脂肪、体重和组织中甘油三酯含量降低。这些结果似乎表明运动可改善胰岛素抵抗。然而，运动同时可能通过升高老年大鼠的LPO而导致内皮依赖性舒张功能受损。
