Rice-Evans C, Spencer J P, Schroeter H, Rechner A R
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Guy 's, King's and St Thomas' School of Biomedical Sciences, London, UK.
Drug Metabol Drug Interact. 2000;17(1-4):291-310. doi: 10.1515/dmdi.2000.17.1-4.291.
Flavonoids are powerful antioxidants in vitro, but their overall functions in vivo have yet to be clarified, whether antioxidant, anti-inflammatory, enzyme inhibitor or inducer, or some other role. The reducing properties of flavonoids might also contribute to redox regulation in cells independently of their antioxidant properties. However, in order to understand their bioactivity in vivo, it is necessary to understand the factors influencing the absorption of flavonoids by the gastrointestinal tract, the nature of the conjugates and metabolites in the circulation and how this influences their antioxidant activities.
黄酮类化合物在体外是强大的抗氧化剂，但其在体内的整体功能尚未明确，无论是抗氧化、抗炎、酶抑制剂或诱导剂，还是其他作用。黄酮类化合物的还原特性也可能独立于其抗氧化特性而有助于细胞内的氧化还原调节。然而，为了了解它们在体内的生物活性，有必要了解影响胃肠道对黄酮类化合物吸收的因素、循环中结合物和代谢物的性质以及这如何影响它们的抗氧化活性。
