Shimofure S, Koizumi S, Ichikawa K, Ichikawa H, Dobashi T
Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University, Kiryu, Japan.
J Microencapsul. 2001 Jan-Feb;18(1):13-7. doi: 10.1080/026520401750038566.
Microcapsules for internal radiation therapies containing the rare-earth metal elements Dy, Ho and Cu with a diameter of 5-10 microm were successfully obtained by an interfacial polymerization method and a successive sedimentation technique was employed to fractionate the microcapsules. A triisocyanate monomer and tricresylphosphate were used for a wall forming material and a core solvent for the metals, respectively. The amount of the metal elements loaded was measured using a high frequency plasma photoemission apparatus. The beta-ray radioactivity of 1 mg of microcapsules irradiated with a common neutron source is estimated as 370 microCi, which is satisfactorily strong for usual radiotherapy, when microcapsules containing Dy are used. Differential interference microscopy indicated narrow size distribution of the fractionated microcapulses.
通过界面聚合法成功制备了用于内照射治疗的含稀土金属元素镝（Dy）、钬（Ho）和铜（Cu）的微胶囊，直径为5 - 10微米，并采用连续沉降技术对微胶囊进行分级分离。分别使用三异氰酸酯单体和磷酸三甲苯酯作为壁材形成材料和金属的核心溶剂。使用高频等离子体光发射仪测量负载的金属元素量。当使用含镝的微胶囊时，用普通中子源辐照1毫克微胶囊的β射线放射性估计为370微居里，这对于常规放疗来说强度令人满意。微分干涉显微镜显示分级分离后的微胶囊尺寸分布狭窄。
