Pérault M C, Favrelière S, Minet P, Remblier C
Service de Pharmacologie Clinique, CRPV, CHU La Milétrie, 350 avenue Jacques Coeur BP 577, 86021 Poitiers, France.
Therapie. 2000 Sep-Oct;55(5):587-95.
The use of benzodiazepines is not negligible in pregnant woman and self-medication is considerable. To investigate the effects on the fetus of benzodiazepines used during pregnancy, we reviewed animal and clinical studies completed with observations of CRPV (Centres Régionaux de Pharmacovigilance). Pooled results indicate that the risk of malformations associated with first-trimester exposure to benzodiazepines remains small. However, in a fetus exposed essentially to long-acting benzodiazepines on a long-term basis, neonatal hypotonicity, failure to feed and/or withdrawal syndrom could be observed.
苯二氮䓬类药物在孕妇中的使用不容忽视，且自我用药的情况相当普遍。为了研究孕期使用苯二氮䓬类药物对胎儿的影响，我们回顾了动物研究和临床研究，并结合了地区药物警戒中心（Centres Régionaux de Pharmacovigilance，CRPV）的观察结果。汇总结果表明，孕早期接触苯二氮䓬类药物导致畸形的风险仍然较小。然而，对于长期主要暴露于长效苯二氮䓬类药物的胎儿，可能会观察到新生儿肌张力减退、拒食和/或戒断综合征。
