Bessmel'tsev S S, Lubo-Lesnichenko I F, Abdulkadyrov K M, Blinov M N, Stel'mashenko L V, Gubarenko N K
Russian Research Institute of Hematology and Transfusiology, St. Petersburg.
Vopr Onkol. 2000;46(5):574-7.
beta 2-microglobulin (beta 2-m) and certain other characteristics of liquor have been followed in the course of multiple myeloma (MM) versus severity of the disease and its response to chemotherapy, to establish the diagnostic and prognostic value of these indices. Lymphocytes and plasma cells were found in most of 17 patients under study, who were resistant to chemotherapy and relapsed; they revealed regular rise in liquor pressure and cytosis. Similarly, raised concentrations of beta 2-m were registered. However, there was no correlation between blood serum-beta 2-m levels and that in cerebrospinal fluid (CSF) nor between CSF-beta 2-m concentration, on the one hand, and such parameters as CSF-total protein, blood serum-beta 2-m and pathologic cytosis, on the other. In advanced MM, CSF-beta 2-m levels were, as a rule, abnormally higher. Our data suggest that, in addition to assaying CSF-total protein, severity of cytosis and liquor pressure as well as morphological identification of detected cells, beta 2-m levels be followed in the course of the disease in MM patients, to make therapeutic correction possible. Moreover, CSF-beta 2-m level dynamics can be used as another factor of prognosis.
在多发性骨髓瘤（MM）病程中，对β2-微球蛋白（β2-m）及脑脊液的某些其他特征与疾病严重程度及其对化疗的反应进行了跟踪研究，以确定这些指标的诊断和预后价值。在17例接受研究的对化疗耐药且复发的患者中，大多数患者的脑脊液中发现了淋巴细胞和浆细胞；这些患者的脑脊液压力和细胞增多呈规律性升高。同样，β2-m的浓度也有所升高。然而，血清β2-m水平与脑脊液（CSF）中的水平之间，以及脑脊液β2-m浓度与脑脊液总蛋白、血清β2-m和病理性细胞增多等参数之间均无相关性。在晚期MM中，脑脊液β2-m水平通常异常升高。我们的数据表明，除了检测脑脊液总蛋白、细胞增多的严重程度和脑脊液压力以及对检测到的细胞进行形态学鉴定外，还应在MM患者的病程中跟踪β2-m水平，以便进行治疗调整。此外，脑脊液β2-m水平动态变化可作为另一个预后因素。
