Kaverina N V, Chichkanov G G, Tsorin I B, Kirsanova G Iu
Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Eksp Klin Farmakol. 2000 Nov-Dec;63(6):22-3.
Experiments with a 7-min occlusion followed by reperfusion of the left coronary artery in narcotized rats showed that antiarrhythmic drugs of various classes--ethacizin (class I), AL-275 (class III), and CM-345 (class V)--produce pronounced antifibrillatory and antiarrhythmic effects. AL-275 and CM-345, in contrast to ethacizin, retained their efficacy under the conditions of isoproterenol-induced stimulation of beta-adrenoceptors. This difference in behavior is probably explained by dissimilar effects of the antiarrhythmics on the ion channels of cardiomyocite membranes.
在麻醉大鼠身上进行的实验显示，对左冠状动脉进行7分钟闭塞然后再灌注，结果表明各类抗心律失常药物——乙胺噻嗪（I类）、AL - 275（III类）和CM - 345（V类）——产生了显著的抗纤颤和抗心律失常作用。与乙胺噻嗪不同，AL - 275和CM - 345在异丙肾上腺素诱导的β - 肾上腺素能受体刺激条件下仍保持其疗效。这种行为差异可能是由于抗心律失常药物对心肌细胞膜离子通道的不同作用所致。
