Chichkanov G G, Tsorin I B, Kirsanova G Iu, Berdiaev S Iu, Turilova A I
Laboratory of Pharmacology and Blood Circulation, Institute of Pharmacology, Russia.
Eksp Klin Farmakol. 1997 Sep-Oct;60(5):35-9.
It was shown in experiments on aconitine, calcium chloride, and epinephrine models of heart rhythm disorders that derivatives of 2-mercaptobenzimidasole possessing the properties of specific bradycardiac agents coded as SM-251, SM-266, and SM-345 cause a marked antiarrhythmic effect. SM-266 and SM-345 reduce considerably the number of ventricular fibrillations and the life-hazardous arrhythmia occurring during 7-min occlusion and subsequent reperfusion of the coronary artery in anesthetized rats. The agents under study reduced the ectopic heart rate in Harris' conscious dogs. It is concluded that the studied 2-mercaptobenzimidasole derivatives exert a marked antiarrhythmic and antifibrillatory effect.
在乌头碱、氯化钙和肾上腺素所致心律失常模型实验中表明，具有特定心动过缓药物特性的2-巯基苯并咪唑衍生物，编码为SM-251、SM-266和SM-345，可产生显著的抗心律失常作用。SM-266和SM-345可显著减少麻醉大鼠冠状动脉7分钟闭塞及随后再灌注期间发生的室颤次数和危及生命的心律失常。所研究的药物降低了哈里斯清醒犬的异位心率。得出结论，所研究的2-巯基苯并咪唑衍生物具有显著的抗心律失常和抗纤颤作用。
