具有抗炎和镇痛活性的N-[4-(丙基)环己基]-酰胺的合成。

Synthesis of N-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities.

作者信息

Pau A, Boatto G, Asproni B, Palomba M, Auzzas L, Cerri R, Palagiano F, Filippelli W, Falcone G, Motola G

机构信息

Dipartimento Farmaco Chimico Tossicologico, Facoltà di Farmacia, Università di Sassari, Italy.

出版信息

Farmaco. 2000 Jun-Jul;55(6-7):439-47. doi: 10.1016/s0014-827x(00)00063-x.

DOI:10.1016/s0014-827x(00)00063-x

PMID:11204744

Abstract

Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a-h, 7a-h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure-activity relationships.

摘要

合成了17种（未）取代的N-[4-（丙基）环己基]酰胺（6a-h、7a-h和8），并作为抗炎和镇痛剂进行了测试。选择芳环上的取代基是为了研究吸电子或供电子基团的影响，这些基团会改变芳环部分的电子密度。药理学结果有助于对构效关系得出一些初步结论。