Shah J J, Shah R J
J Assoc Off Anal Chem. 1976 Nov;59(6):1416-8.
Thin layer chromatographic behavior of some sympathomimetic amines in the presence of acids in neutral and organic solvent systems is reported. The sympathomimetic amines were dissolved in 0.1N HCl or ethanol and treated with bromocresol green or p-nitrobenzoyl chloride reagents on fiber sheets or precoated glass plates. Two-, 3-, and 4-, component solvent systems were tested. Benzene-ethyl acetate gave 2 spots for each amine standard; the more polar spots were satisfactorily separated. Amines in pharmaccuticals were not separated by any solvent system tested.
报道了一些拟交感神经胺类在中性和有机溶剂体系中、存在酸的情况下的薄层色谱行为。将拟交感神经胺类溶解于0.1N盐酸或乙醇中，并在纤维板或预涂玻璃板上用溴甲酚绿或对硝基苯甲酰氯试剂处理。测试了二元、三元和四元溶剂体系。苯 - 乙酸乙酯使每种胺标准品产生2个斑点；极性较强的斑点得到了满意的分离。所测试的任何溶剂体系均未分离出药物中的胺类。
