Hydraphile channels: models for transmembrane, cation-conducting transporters.
作者信息
Gokel G W, Ferdani R, Liu J, Pajewski R, Shabany H, Uetrecht P
机构信息
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
Chemistry. 2001 Jan 5;7(1):33-9. doi: 10.1002/1521-3765(20010105)7:1<33::aid-chem33>3.0.co;2-3.
Abstract
A completely synthetic, non-peptide channel has been prepared and shown to conduct cations across a phospholipid bilayer membrane. Studies have been undertaken to assess the compound's location within the bilayer and to better understand its function. These studies are described along with background on the design and concept of the channel.
摘要
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