The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel.
作者信息
Pechulis A D, Thompson R J, Fojtik J P, Schwartz H M, Lisek C A, Frye L L
机构信息
Department of Chemistry, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
出版信息
Bioorg Med Chem. 1997 Oct;5(10):1893-901. doi: 10.1016/s0968-0896(97)00085-0.
PMID:9370033
Abstract
A model sterol-based ion channel was rationally designed and synthesized. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule 1a was incorporated into phospholipid vesicles and shown to facilitate the transmembrane transport of sodium and lithium ions using alkali metal NMR spectroscopy.
摘要
Zotero 插件