Berger T, Reindl M
Department of Neurology, University of Innsbruck, Austria.
J Neural Transm Suppl. 2000(60):351-60. doi: 10.1007/978-3-7091-6301-6_25.
Recent neuropathological findings identified four distinct immunopathogenic pathways of demyelination and tissue destruction in the most common inflammatory demyelinating central nervous system disorder, Multiple Sclerosis. One of this neuropathological subtypes is characterised by features of antibody-mediated demyelination. A role of anti-myelin antibodies in the disease evolution of multiple sclerosis has been suggested already for a long time, however, their pathogenetic and clinical relevance is not understood yet. This present article will discuss recently published and some preliminary data on the immunopathogenic role of antibodies against myelin oligodendrocyte glycoprotein (MOG) and other myelin/nonmyelin targets in multiple sclerosis, as well as possible clinical implications for prognosis and therapy in the future.
最近的神经病理学研究结果表明，在最常见的炎症性脱髓鞘中枢神经系统疾病——多发性硬化症中，存在四种不同的免疫致病途径导致脱髓鞘和组织破坏。这种神经病理学亚型之一的特征是抗体介导的脱髓鞘。抗髓鞘抗体在多发性硬化症疾病演变中的作用早已被提出，然而，它们的发病机制和临床相关性尚不清楚。本文将讨论最近发表的以及一些关于抗髓鞘少突胶质细胞糖蛋白（MOG）和其他髓鞘/非髓鞘靶点抗体在多发性硬化症中的免疫致病作用的初步数据，以及未来对预后和治疗可能的临床意义。
