Hinterberger W
Ludwig-Boltzmann-Institut für Stammzelltransplantation, 2. Medizinische Abteilung des Donauspitals, SMZ-Ost der Stadt Wien, Langobardenstrasse 122, A-1220 Wien.
Wien Med Wochenschr. 2000;150(23-24):476-80.
Chronic hepatitis comprises a group of disorders of the liver exhibiting a chronic necroinflammatory process that differs in etiology, clinical course and treatment strategies. A diagnosis of chronic hepatitis is usually made when inflammation and liver cell necrosis persist for longer than 6 months. Clinical manifestations range from asymptomatic patients to those with advanced hepatic failure. Both sexes and all age groups are affected. Chronic hepatitis may emerge as a sequelae of hepatitis C and less often after hepatitis B. Both diseases are treatable and require rapid and exact diagnosis. The differential diagnosis must exclude autoimmune hepatitis, chronic steatohepatitis, congenital metabolic hepatopathies and drug-induced hepatopathies. Laboratory tests, histologic investigations and clinical differential diagnosis must exclude other causes of chronic liver disease.
慢性肝炎包括一组肝脏疾病,其呈现出一种慢性坏死性炎症过程,在病因、临床病程和治疗策略方面存在差异。当炎症和肝细胞坏死持续超过6个月时,通常会做出慢性肝炎的诊断。临床表现从无症状患者到晚期肝衰竭患者不等。男女两性及所有年龄组均可受累。慢性肝炎可能作为丙型肝炎的后遗症出现,较少见于乙型肝炎之后。这两种疾病都是可治疗的,并且需要快速、准确的诊断。鉴别诊断必须排除自身免疫性肝炎、慢性脂肪性肝炎、先天性代谢性肝病和药物性肝病。实验室检查、组织学检查和临床鉴别诊断必须排除慢性肝病的其他病因。