可卡因催化抗体：连接子效应的首要重要性。
Cocaine catalytic antibodies: the primary importance of linker effects.
作者信息
Matsushita M, Hoffman T Z, Ashley J A, Zhou B, Wirsching P, Janda K D
机构信息
The Scripps Research Institute and the Skaggs Institute for Chemical Biology, Department of Chemistry, La Jolla, CA 92037, USA.
出版信息
Bioorg Med Chem Lett. 2001 Jan 22;11(2):87-90. doi: 10.1016/s0960-894x(00)00659-4.
Current treatments for cocaine addiction are not effective. The development of a catalytic monoclonal antibody (mAb) provides a strategy for not only binding, but also degrading cocaine, which offers a broad-based therapy. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analogue phosphonate haptens were shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.
目前治疗可卡因成瘾的方法并不有效。催化单克隆抗体（mAb）的研发不仅提供了一种结合可卡因的策略，还提供了一种降解可卡因的策略，从而提供了一种基础广泛的治疗方法。半抗原设计是设计抗体催化作用的核心要素。经典的过渡态类似物膦酸酯半抗原中使用的连接子特性，对于获得能水解可卡因苯甲酸酯的单克隆抗体很重要。
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