抗可卡因疫苗的研制。
Anti-cocaine vaccine development.
机构信息
Veterans Affairs Medical Center, TX, USA.
出版信息
Expert Rev Vaccines. 2010 Sep;9(9):1109-14. doi: 10.1586/erv.10.102.
Abstract
Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At present, there are no effective pharmacological agents available to treat the addiction by blocking cocaine or reversing its effects. In order to help motivated addicts conquer their addiction, vaccines against cocaine are being developed and one has progressed to clinical trials. This article will discuss the concept of antidrug vaccines in general, the successes and limitations of the various anti-cocaine vaccine approaches, the results of the clinical trials with an anti-cocaine vaccine and some new vaccine-mediated approaches to combat cocaine addiction.
摘要
可卡因滥用是一个持续存在且严重的问题，导致了残酷的犯罪企业的发展，特别是在美洲和欧洲。目前，没有有效的药理学药物可用于通过阻断可卡因或逆转其作用来治疗成瘾。为了帮助有动机的成瘾者克服他们的成瘾，正在开发针对可卡因的疫苗，其中一种已经进展到临床试验阶段。本文将讨论一般的戒毒疫苗概念，各种抗可卡因疫苗方法的成功和局限性，抗可卡因疫苗的临床试验结果以及一些新的疫苗介导的方法来对抗可卡因成瘾。
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本文引用的文献
1
Structural analysis of thermostabilizing mutations of cocaine esterase.热稳定可卡因酯酶突变体的结构分析。
Protein Eng Des Sel. 2010 Jul;23(7):537-47. doi: 10.1093/protein/gzq025. Epub 2010 Apr 30.
2
Pharmacotherapy in the treatment of addiction: methadone.药物治疗成瘾：美沙酮。
J Addict Dis. 2010 Apr;29(2):200-16. doi: 10.1080/10550881003684798.
3
The concept of pharmacologic cocaine interception as a treatment for drug abuse.作为药物滥用治疗方法的药物可卡因截获概念。
Chem Biol Interact. 2010 Sep 6;187(1-3):421-4. doi: 10.1016/j.cbi.2010.02.036. Epub 2010 Feb 26.
4
Nicotine hapten structure, antibody selectivity and effect relationships: results from a nicotine vaccine screening procedure.尼古丁半抗原结构、抗体选择性和效应关系：来自尼古丁疫苗筛选程序的结果。
Vaccine. 2010 Mar 2;28(10):2161-2168. doi: 10.1016/j.vaccine.2009.12.051. Epub 2010 Jan 7.
5
Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans.可卡因特异性抗体削弱了人类吸食可卡因后的主观感受。
Biol Psychiatry. 2010 Jan 1;67(1):59-65. doi: 10.1016/j.biopsych.2009.08.031.
6
Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.用于治疗美沙酮维持治疗患者可卡因依赖的可卡因疫苗：一项随机、双盲、安慰剂对照的疗效试验。
Arch Gen Psychiatry. 2009 Oct;66(10):1116-23. doi: 10.1001/archgenpsychiatry.2009.128.
7
Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach.新纹状体中可卡因作用的持久降低——一种水解酶基因治疗方法。
J Pharmacol Exp Ther. 2009 Aug;330(2):449-57. doi: 10.1124/jpet.109.152231. Epub 2009 May 28.
8
Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines.通过使用基于肽的含分子佐剂疫苗进行主动免疫来对甲基苯丙胺产生免疫反应。
Vaccine. 2009 May 14;27(22):2981-8. doi: 10.1016/j.vaccine.2009.02.105. Epub 2009 Mar 10.
9
Development of active and passive human vaccines to treat methamphetamine addiction.用于治疗甲基苯丙胺成瘾的主动和被动人类疫苗的研发。
Hum Vaccin. 2009 Apr;5(4):206-13. doi: 10.4161/hv.5.4.7456. Epub 2009 Apr 20.
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Neuropsychopharmacology. 2008 Oct;33(11):2715-25. doi: 10.1038/sj.npp.1301666. Epub 2008 Jan 16.
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