Catelli M, Monassier L, Feldman J, Tibiriçá E
Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Fundam Clin Pharmacol. 2000 Nov-Dec;14(6):587-92. doi: 10.1111/j.1472-8206.2000.tb00444.x.
In the present study we investigated the effects of a long-term treatment (14 days) with ifenprodil on the excitatory haemodynamic responses induced by central pharmacological stimulation in anaesthetised rabbits. The intracerebroventricular injection of L-glutamate (3 mg/kg) induced important rises in dP/dtmax (32.9%), mean arterial pressure (42.6%) and in the myocardial oxygen consumption index: the triple product (84.2%). Ifenprodil (1.5, 3 and 6 mg/kg/day, i.p.) reduced the increases in myocardial oxygen demand induced by intracerebral L-glutamate in a dose-related manner. Interestingly, ifenprodil also reduced in a dose-dependent manner the maximum values of the oxygen demand indices reached during the central nervous system stimulation. These results indicate that the long-term treatment with ifenprodil can reduce the myocardial oxygen consumption induced by central nervous system stimulation without significant depression of the resting cardiac function. This favourable effect of ifenprodil is in fact a consequence of the association of mild inhibitory effects on the three parameters taken into account in the triple product index of myocardial oxygen consumption.
在本研究中，我们调查了长期（14天）给予艾芬地尔对麻醉兔中枢药理学刺激所诱发的兴奋性血流动力学反应的影响。脑室内注射L-谷氨酸（3mg/kg）可使dp/dtmax显著升高（32.9%）、平均动脉压升高（42.6%）以及心肌耗氧量指数——三联乘积升高（84.2%）。艾芬地尔（1.5、3和6mg/kg/天，腹腔注射）以剂量相关的方式降低了脑内L-谷氨酸所诱发的心肌需氧量的增加。有趣的是，艾芬地尔还以剂量依赖的方式降低了中枢神经系统刺激期间所达到的需氧量指数的最大值。这些结果表明，长期给予艾芬地尔可降低中枢神经系统刺激所诱发的心肌耗氧量，而不会显著抑制静息心脏功能。艾芬地尔的这种有利作用实际上是对心肌耗氧量三联乘积指数中所考虑的三个参数产生轻度抑制作用的结果。
