Parental cigarette smoking, hard liquor consumption and the risk of childhood brain tumors--a case-control study in northeast China.

In this study we examine the effect of parents' lifestyles on the risk of childhood brain tumors. Parents of 82 children newly diagnosed with primary malignant brain tumors and 246 individually matched hospital controls were interviewed in the hospital wards between September 1991 and December 1996. Data were collected on socioeconomic status, parental lifestyle prior to and during the pregnancy, and family history. Odds ratios and 95% confidence intervals were derived through conditional logistic regression. The risk of childhood brain tumors was associated with paternal use of hard liquor prior to the pregnancy: the odds ratios were 3.72 (95% CI = 1.91-7.26) for < or = 15 years of hard liquor consumption and 4.06 (95% CI = 1.09-15.21) for > or = 16 years of hard liquor consumption compared with never consuming hard liquor (test for trend p = 0.0001); the odds ratios increased with increasing lifetime hard liquor consumption. There is little evidence to support an association between childhood brain tumors and parents' smoking prior to or during pregnancy.