肾上腺皮质功能不全的早产儿难治性低血压。
Refractory hypotension in preterm infants with adrenocortical insufficiency.
作者信息
Ng P C, Lam C W, Fok T F, Lee C H, Ma K C, Chan I H, Wong E
机构信息
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2001 Mar;84(2):F122-4. doi: 10.1136/fn.84.2.f122.
Abstract
Five preterm, very low birthweight infants with severe hypotension and adrenocortical insufficiency are described. The profound hypotension was resistant to volume expansion and inotrope treatment, but responded promptly to corticosteroid treatment. A human corticotrophin releasing hormone (hCRH) test performed before corticosteroid treatment showed adequate pituitary response, and the endocrine dysfunction was identified at the adrenal level. Corticosteroid treatment should be considered and could be life saving in severely hypotensive preterm infants who do not respond to conventional treatment with volume expanders and inotropes.
摘要
本文描述了5例患有严重低血压和肾上腺皮质功能不全的早产极低出生体重儿。严重的低血压对扩容和使用血管活性药物治疗无效，但对皮质类固醇治疗反应迅速。在使用皮质类固醇治疗前进行的人促肾上腺皮质激素释放激素（hCRH）试验显示垂体反应正常，内分泌功能障碍定位于肾上腺水平。对于对传统的扩容剂和血管活性药物治疗无反应的严重低血压早产儿，应考虑使用皮质类固醇治疗，这可能挽救生命。
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本文引用的文献
1
LESIONS IN THE ADRENALS OF AN INFANT FOLLOWING MATERNAL CORTICOSTEROID THERAPY.
Bull Johns Hopkins Hosp. 1964 Feb;114:146-51.
2
The fetal and neonatal hypothalamic-pituitary-adrenal axis.胎儿及新生儿下丘脑-垂体-肾上腺轴
Arch Dis Child Fetal Neonatal Ed. 2000 May;82(3):F250-4. doi: 10.1136/fn.82.3.f250.
3
Single-dose dexamethasone treatment of hypotension in preterm infants.单剂量地塞米松治疗早产儿低血压
J Pediatr. 1999 Jun;134(6):701-5. doi: 10.1016/s0022-3476(99)70284-2.
4
Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants.细胞因子、黏附分子及C反应蛋白用于诊断早产极低出生体重儿迟发型新生儿败血症
Arch Dis Child Fetal Neonatal Ed. 1997 Nov;77(3):F221-7. doi: 10.1136/fn.77.3.f221.
5
Procalcitonin aids diagnosis of adrenocortical failure.降钙素原有助于肾上腺皮质功能减退的诊断。
Lancet. 1997 Dec 13;350(9093):1749-50. doi: 10.1016/s0140-6736(05)63573-8.
6
Pituitary-adrenal response in preterm very low birth weight infants after treatment with antenatal corticosteroids.产前使用糖皮质激素治疗后早产极低出生体重儿的垂体-肾上腺反应
J Clin Endocrinol Metab. 1997 Nov;82(11):3548-52. doi: 10.1210/jcem.82.11.4392.
7
Randomised trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants.多巴胺与氢化可的松治疗低血压极低出生体重儿的随机试验。
Arch Dis Child Fetal Neonatal Ed. 1997 May;76(3):F174-8. doi: 10.1136/fn.76.3.f174.
8
The pituitary-adrenal responses to exogenous human corticotropin-releasing hormone in preterm, very low birth weight infants.早产极低出生体重儿垂体-肾上腺对外源性人促肾上腺皮质激素释放激素的反应。
J Clin Endocrinol Metab. 1997 Mar;82(3):797-9. doi: 10.1210/jcem.82.3.3832.
9
Addison's disease.艾迪生病
BMJ. 1996 Apr 27;312(7038):1085-7. doi: 10.1136/bmj.312.7038.1085.
10
The effectiveness and side effects of dexamethasone in preterm infants with bronchopulmonary dysplasia.地塞米松对支气管肺发育不良早产儿的疗效及副作用
Arch Dis Child. 1993 Mar;68(3 Spec No):330-6. doi: 10.1136/adc.68.3_spec_no.330.
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