Lopez O L, Zivkovic S, Smith G, Becker J T, Meltzer C C, DeKosky S T
Alzheimer's Disease Research Center and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
J Neuropsychiatry Clin Neurosci. 2001 Winter;13(1):56-60. doi: 10.1176/jnp.13.1.56.
Positron emission tomography was used to evaluate 3 Alzheimer's disease (AD) patients: 1 with major depression, 1 with emotional lability, and 1 with apathy. Compared with 5 non-mood-disordered AD patients, the patient with depression had diminished relative regional cerebral blood flow (rel-CBF) in the anterior cingulate and superior temporal cortices, bilaterally. This patient also showed diminished rel-CBF in the left dorsolateral prefrontal and right medial temporal and parietal cortices. The patient with emotional lability had diminished rel-CBF in the anterior cingulate and dorsolateral prefrontal cortices, bilaterally, and left basal ganglia. The patient with apathy had diminished rel-CBF in the basal ganglia and dorsolateral prefrontal cortex, bilaterally. Results are consistent with the hypothesis of a common frontal-temporal-subcortical substrate (e.g., involving aminergic nuclei) in the etiology of depression in AD. Frontal-subcortical dysfunction may also be associated with emotional lability and apathy in AD, although these may be related to a greater involvement of frontal-basal ganglia circuits.
正电子发射断层扫描术用于评估3例阿尔茨海默病（AD）患者：1例伴有重度抑郁，1例伴有情绪不稳，1例伴有淡漠。与5例无情绪障碍的AD患者相比，伴有抑郁的患者双侧前扣带回和颞上叶皮质的相对局部脑血流量（rel-CBF）减少。该患者左侧背外侧前额叶、右侧颞内侧和顶叶皮质的rel-CBF也减少。伴有情绪不稳的患者双侧前扣带回和背外侧前额叶皮质以及左侧基底神经节的rel-CBF减少。伴有淡漠的患者双侧基底神经节和背外侧前额叶皮质的rel-CBF减少。结果与AD抑郁病因中存在常见的额颞叶-皮质下基质（如涉及胺能核团）这一假说一致。额皮质下功能障碍也可能与AD中的情绪不稳和淡漠有关，尽管这些可能与额基底神经节回路的更大参与有关。
