Morimoto-Ishizuka T, Yamamoto Y, Yamatodani A
Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Suita, Japan.
Neurosci Lett. 2001 Mar 9;300(2):107-10. doi: 10.1016/s0304-3940(01)01566-x.
A possible pathway through which leptin activates the histaminergic system was studied using in vivo microdialysis in rats. Intraperitoneal injection of leptin (1.3 mg/kg) caused a significant increase in hypothalamic histamine release, however, its intracerebroventricular injection (10 microg/rat) did not cause any significant changes in the release. Furthermore, leptin (1.3 mg/kg) had no effect on histamine release in rats whose chorda tympani nerves, a branch of the facial nerve which mediates taste information, were transected bilaterally. These findings indicate that leptin activates the histaminergic system by the peripheral signal inputs via the chorda tympani resulting in the suppression of food intake.
利用大鼠体内微透析技术研究了瘦素激活组胺能系统的一种可能途径。腹腔注射瘦素（1.3毫克/千克）可导致下丘脑组胺释放显著增加，然而，脑室内注射（10微克/只大鼠）并未引起释放的任何显著变化。此外，瘦素（1.3毫克/千克）对双侧切断鼓索神经（介导味觉信息的面神经分支）的大鼠的组胺释放没有影响。这些发现表明，瘦素通过经由鼓索的外周信号输入激活组胺能系统，从而导致食物摄入的抑制。
