Kluger M J, D'Alecy L G
J Appl Physiol. 1975 Feb;38(2):268-71. doi: 10.1152/jappl.1975.38.2.268.
Seven male New Zealand white rabbits were trained to run in an exercise wheel. At least 5 days prior to experimentation, each rabbit had a reversible tracheal bypass canula and a hypothalamic thermocouple guide tube chronically implanted. The reversible tracheal bypass enabled the rabbit to breathe normally (through its upper respiratory pathways) or to be placed on bypass (breathe through its neck). Prior to and following exercise, hypothalamic temperature in rabbits breathing normally was lower than rectal temperature. This difference was greatest following a mild heat stress induced by exercise. When the rabbits breathed through the bypass, there were no differences between hypothalamic and rectal temperature. These data suggest that even in a species such as the rabbit, which lacks a carotid rate, hypothalamic temperature is influenced by upper respiratory cooking of venous blood and that the ensuing transfer of heat from the warmer internal carotid artery to the cooler venous sinuses can effectively cool the brain.
七只雄性新西兰白兔被训练在运动轮上跑步。在实验前至少5天，每只兔子都被长期植入了一个可逆转的气管旁路插管和一个下丘脑热电偶导管。可逆转的气管旁路使兔子能够正常呼吸（通过其上呼吸道途径）或进行旁路通气（通过其颈部呼吸）。运动前后，正常呼吸的兔子下丘脑温度低于直肠温度。这种差异在运动引起的轻度热应激后最大。当兔子通过旁路呼吸时，下丘脑温度和直肠温度之间没有差异。这些数据表明，即使在像兔子这样没有颈动脉体的物种中，下丘脑温度也会受到静脉血上呼吸道加温的影响，并且随之而来的热量从较温暖的颈内动脉向较凉爽的静脉窦的传递可以有效地冷却大脑。
