Hanlon J T, Schmader K E, Ruby C M, Weinberger M
Institute for the Study of Geriatric Pharmacotherapy and the Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis 55455, USA.
J Am Geriatr Soc. 2001 Feb;49(2):200-9. doi: 10.1046/j.1532-5415.2001.49042.x.
Investigators searched Medline and HealthSTAR databases from January 1, 1985 through June 30, 1999 to identify articles on suboptimal prescribing in those age 65 years and older. A manual search of the reference lists from identified articles and the authors' article files, book chapters, and recent reviews was conducted to identify additional articles. The definitions for various types of suboptimal prescribing (polypharmacy, inappropriate, and underutilization) are numerous, and measurement varies from study to study. The literature suggests that suboptimal prescribing is common in older outpatients and inpatients. Moreover, there is significant morbidity and mortality associated with suboptimal prescribing for these older patients. Evidence from well-controlled studies suggests that multidisciplinary teams and clinical pharmacy interventions can modify suboptimal drug use in older people. Future research is necessary to measure and test other methods for tackling this major public health problem facing older people.
研究人员检索了1985年1月1日至1999年6月30日期间的Medline和HealthSTAR数据库，以查找有关65岁及以上老年人用药不当的文章。对已识别文章的参考文献列表以及作者的文章档案、书籍章节和近期综述进行了人工检索，以识别其他文章。各种类型用药不当（多重用药、不适当用药和用药不足）的定义众多，且不同研究中的测量方法各异。文献表明，用药不当在老年门诊患者和住院患者中很常见。此外，这些老年患者的用药不当会导致显著的发病率和死亡率。来自严格对照研究的证据表明，多学科团队和临床药学干预可以改变老年人的用药不当情况。有必要开展未来研究，以衡量和测试应对老年人面临的这一重大公共卫生问题的其他方法。
