无胃肠道症状的身材矮小儿童中肌内膜抗体在乳糜泻诊断中的应用
Endomysium antibodies in the diagnosis of celiac disease in short-statured children with no gastrointestinal symptoms.
作者信息
Tümer L, Hasanoglu A, Aybay C
机构信息
Department of Pediatrics, Gazi University, School of Medicine, Ankara, Turkey.
出版信息
Pediatr Int. 2001 Feb;43(1):71-3. doi: 10.1046/j.1442-200x.2001.01327.x.
BACKGROUND
Endomysium antibodies (EmAb) are strongly associated with untreated celiac disease and are suggested to be diagnostic. The aim of the present study was to assess the value of anti-EmAb for celiac disease screening in children with short stature.
METHODS
In 84 children with height less than the third percentile for age, preliminary work-ups were made to find a cause for their short stature and then their serum was assayed for anti-EmAb by indirect immunofluorescence tests using monkey esophagus.
RESULTS
Seven children were strongly positive for EmAb and all had positive histologic findings for celiac disease.
CONCLUSIONS
Our results show that there is an association with occult celiac disease and idiopathic short stature and that the serum anti-EmAb test is useful in identifying such cases.
背景
肌内膜抗体（EmAb）与未经治疗的乳糜泻密切相关，被认为具有诊断价值。本研究旨在评估抗EmAb在身材矮小儿童乳糜泻筛查中的价值。
方法
对84名身高低于年龄第三百分位数的儿童进行初步检查，以寻找其身材矮小的原因，然后用猴食管通过间接免疫荧光试验检测他们血清中的抗EmAb。
结果
7名儿童EmAb呈强阳性，所有儿童乳糜泻组织学检查结果均为阳性。
结论
我们的结果表明，隐匿性乳糜泻与特发性身材矮小之间存在关联，血清抗EmAb检测有助于识别此类病例。
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