Wojtacki J, Lewicka-Nowak E, Leśniewski-Kmak K
Department of Radiotherapy, Polish Red Cross Marine Hospital, Gdynia-Redłowo, Poland.
Med Sci Monit. 2000 Mar-Apr;6(2):411-20.
Anthracycline antibiotics are widely used antineoplastic agents and their efficacy for the treatment of various haemopoietic or solid tumours has been well established in clinical practice. Cardiotoxicity is one of the most serious side effects of anthracyclines. The risk of cumulative, life-threatening toxic cardiomyopathy limits their therapeutic potential. In this article, acute, subacute, chronic and late-onset cardiac function impairment associated with anthracycline administration has been characterised. The current views on the methods of detection, pathogenesis and prevention of such toxicity have been reviewed.
蒽环类抗生素是广泛使用的抗肿瘤药物，其在治疗各种血液系统或实体肿瘤方面的疗效已在临床实践中得到充分证实。心脏毒性是蒽环类药物最严重的副作用之一。累积性、危及生命的毒性心肌病风险限制了它们的治疗潜力。在本文中，已对与蒽环类药物给药相关的急性、亚急性、慢性和迟发性心功能损害进行了特征描述。已对目前关于此类毒性的检测方法、发病机制和预防的观点进行了综述。
