Bartuzi Z, Korenkiewicz J, Romański B
Chair and Department of Allergology and Internal Diseases, Medical University, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Med Sci Monit. 2000 May-Jun;6(3):530-8.
The purpose of this study was to evaluate the intensity of gastric inflammatory changes in atopic patients infected with H. pylori, and to find out whether a long-term exposure to a sensitizing allergen intensified the acuteness of inflammatory changes. The examinations were performed on patients with atopic diathesis who suffered from dyspepsia and gastralgia. The examined group included 72 women between 16 and 57 years of age (mean age: 36.5 years) and 38 men from 16 to 60 years of age (mean age: 34.4 years). The control group included 40 patients with no traits of atopy (13 men and 27 women between 18 and 56 years old, mean age: 34.8 years) with chronic gastritis confirmed by endoscopic and histopathological tests. All patients were subjected to endoscopy of the upper alimentary tract. Biopsy specimens were taken for histopathological analyses. They were stained with eosin and hematoxylin (the H&E method), and with a modified Giemsa method. The evaluation included the presence of chronic inflammation of gastric mucosa, its activity and intensity. The presence of H. pylori colonization was determined with the use of histopathological method of staining. Significant differences were found concerning inflammation intensity in atopic patients additionally infected with H. pylori, in comparison with the group of patients with food allergy without bacterial colonization. The differences were found during the evaluation of mucosa of both the prepyloric area and body of the stomach (p < 0.001). Moreover, statistically significant differences were found in the inflammation intensity between the examined group and the control group with no symptoms of allergy. In atopic patients infected with Helicobacter pylori, a long-term exposure to food allergens increases the intensity of gastric mucosa inflammation.
本研究的目的是评估感染幽门螺杆菌的特应性患者胃部炎症变化的强度，并探究长期暴露于致敏变应原是否会加剧炎症变化的急性程度。对患有消化不良和胃痛的特应性素质患者进行了检查。被检查组包括72名年龄在16至57岁之间的女性（平均年龄：36.5岁）和38名年龄在16至60岁之间的男性（平均年龄：34.4岁）。对照组包括40名无特应性特征的患者（13名男性和27名女性，年龄在18至56岁之间，平均年龄：34.8岁），经内镜和组织病理学检查确诊为慢性胃炎。所有患者均接受了上消化道内镜检查。采集活检标本进行组织病理学分析。标本用伊红和苏木精（苏木精-伊红染色法）以及改良吉姆萨染色法染色。评估内容包括胃黏膜慢性炎症的存在情况、其活性和强度。采用组织病理学染色方法确定幽门螺杆菌的定植情况。与无细菌定植的食物过敏患者组相比，发现额外感染幽门螺杆菌的特应性患者在炎症强度方面存在显著差异。在评估胃幽门管区和胃体黏膜时发现了这些差异（p < 0.001）。此外，在被检查组和无过敏症状的对照组之间，炎症强度也存在统计学上的显著差异。在感染幽门螺杆菌的特应性患者中，长期暴露于食物变应原会增加胃黏膜炎症的强度。
