Birketvedt G S, Thom E, Bernersen B, Florholmen J
Laboratory of Gastroenterology, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
Med Sci Monit. 2000 Jul-Aug;6(4):699-703.
The aim of the study was to investigate the long term effect of diet, exercise and intermittent treatment of cimetidine on body weight and maintenance of weight lost during treatment.
Fifty women and five men who had completed a 8 week randomized double-blind, placebo-controlled trial of cimetidine for weight loss were invited to participate in an open, non-randomized follow-up study of 42 months. The study was designed to compare weight loss and/or weight gain in subjects who, dependent on their level of motivation, volunteered to participate in an intervention or non-intervention group. In the intervention group the subjects were treated with cimetidine for 8 weeks twice a year, followed a diet restriction and performed regular exercise. In the non-intervention group the subjects had no behavioral treatment. Twenty two subjects volunteered to participate in the intervention program whereas 33 subjects volunteered to participate in the non-intervention group.
In the intervention group, non-significant reductions in body weight (1.9 +/- 5.5 kg), BMI (0.6 +/- 1.7 kg/m2), body fat% (1.7 +/- 2.9) and waist circumference (2.1 +/- 5.9 cm) were found. In the non-intervention group there was a significant increase in body weight (7.5 +/- 5.3 kg), BMI (2.6 +/- 1.8 kg/m2), body fat% (3.0 +/- 3.3) and waist circumference (6.7 +/- 5.1 cm). Among the group of subjects initially treated with cimetidine for 8 weeks and who followed a subsequent intervention of additional 42 months (n = 16), there was a 15.1% weight loss. Among the group initially treated with placebo for 8 weeks and who volunteered to participate in the non-intervention group (n = 22), there was a weight gain of 8.6%. In conclusion, the combination of diet restriction, regular exercise and intermittent treatment of cimetidine appears to have long term effects on body weight and maintenance of weight loss.
本研究的目的是调查饮食、运动以及西咪替丁间歇治疗对体重的长期影响，以及治疗期间体重减轻后的维持情况。
五十名女性和五名男性完成了为期8周的西咪替丁减肥随机双盲、安慰剂对照试验，他们被邀请参加一项为期42个月的开放、非随机随访研究。该研究旨在比较根据自身积极性自愿参加干预组或非干预组的受试者的体重减轻和/或体重增加情况。在干预组中，受试者每年接受两次为期8周的西咪替丁治疗，遵循饮食限制并进行定期运动。在非干预组中，受试者不接受行为治疗。22名受试者自愿参加干预计划，而33名受试者自愿参加非干预组。
在干预组中，体重（1.9±5.5千克）、体重指数（BMI，0.6±1.7千克/平方米）、体脂百分比（1.7±2.9）和腰围（2.1±5.9厘米）有不显著的下降。在非干预组中，体重（7.5±5.3千克）、BMI（2.6±1.8千克/平方米）、体脂百分比（3.0±3.3）和腰围（6.7±5.1厘米）有显著增加。在最初接受8周西咪替丁治疗并随后进行额外42个月干预的受试者组（n = 16）中，体重减轻了15.1%。在最初接受8周安慰剂治疗并自愿参加非干预组的受试者组（n = 22）中，体重增加了8.6%。总之，饮食限制、定期运动和西咪替丁间歇治疗的组合似乎对体重和体重减轻的维持有长期影响。
