Jankowska E A, Rogucka E, Medraś M, Welon Z
Institute of Anthropology, Polish Academy of Sciences, ul. Kuźnicza 35, 50-951 Wrocław, Poland.
Med Sci Monit. 2000 Nov-Dec;6(6):1159-64.
During the process of aging in males a trend toward an unfavourable body fat accumulation, especially within the visceral depots, is observed. This fact is presumed to be associated with the age-related decline in androgen levels among aging men. The aim of this study was to determine the relationships between sex steroid levels (DHEAS, estradiol, free and total testosterone) and BMI, percent fat mass, WHR values in 190 healthy and professionally active men, aged 22-67, inhabitants of the city of Wroclaw, Poland. Hormonal levels were measured using standard immunoassays. BMI was used as a measurement of obesity. Obesity was also assessed using percent fat mass equations according to the Crook formula. WHR was used as an index of fat distribution. All the correlations between sex steroids, BMI, WHR, percent fat mass and age were evaluated using statistical non-parametric analyses (Spearman coefficient) in the entire group of examined subjects, and in two age-specific groups: a) younger males (aged 22-39) and b) older males (aged 40-67). The aging of Polish males is accompanied by both a significant increase of BMI, percent fat mass and WHR values, and by a decline in estradiol, gonadal and adrenal androgen levels. In the younger group only total testosterone levels were significantly negatively related to BMI, percent fat mass and WHR. Within the group of older men both estradiol and DHEAS levels are significantly positively related to WHR. The sex steroids seem to be associated with indices of overall obesity and distribution of fat in men, but these relationships differ considerably when they are evaluated in younger and older age categories. Worthy of notice is the fact that free testosterone levels are not related to any anthropometric parameters in any age category, although free testosterone (not total testosterone) is commonly recognised as a reliable and sensitive endocrinological indicator of the general psycho-physical status of an aging man.
在男性衰老过程中，观察到一种不利于身体脂肪堆积的趋势，尤其是在内脏脂肪库中。这一事实被认为与老年男性雄激素水平随年龄增长而下降有关。本研究的目的是确定190名年龄在22 - 67岁、居住在波兰弗罗茨瓦夫市的健康且职业活跃男性的性类固醇水平（硫酸脱氢表雄酮、雌二醇、游离睾酮和总睾酮）与体重指数（BMI）、体脂百分比、腰臀比（WHR）值之间的关系。激素水平采用标准免疫分析法进行测定。BMI用作肥胖的衡量指标。肥胖也根据克鲁克公式使用体脂百分比方程进行评估。WHR用作脂肪分布指标。在整个受检对象组以及两个特定年龄组中，即a）年轻男性（22 - 39岁）和b）老年男性（40 - 67岁），使用统计非参数分析（斯皮尔曼系数）评估性类固醇、BMI、WHR、体脂百分比与年龄之间的所有相关性。波兰男性的衰老伴随着BMI、体脂百分比和WHR值的显著增加，以及雌二醇、性腺和肾上腺雄激素水平的下降。在较年轻组中，仅总睾酮水平与BMI、体脂百分比和WHR显著负相关。在老年男性组中，雌二醇和硫酸脱氢表雄酮水平均与WHR显著正相关。性类固醇似乎与男性总体肥胖指标和脂肪分布有关，但在年轻和老年类别中进行评估时，这些关系有很大差异。值得注意的是，游离睾酮水平在任何年龄类别中均与任何人体测量参数无关，尽管游离睾酮（而非总睾酮）通常被认为是老年男性总体心理 - 生理状态的可靠且敏感的内分泌指标。
