Burdan F, Burak B, Sek A
Experimental Teratology Unit, Department of Human Anatomy, Medical University, ul. Spokojna 1, 20-074 Lublin, Poland.
Med Sci Monit. 2001 Jan-Feb;7(1):89-92.
Omeprazole is a proton pump inhibitor of increasingly wide application in the treatment of different gastroenterological diseases. The purpose of the study was to evaluate the effect of omeprazole (O) on the level of plasma malondialdehyde (MDA).
Omeprazole was administered intraperitoneally to male Wistar rats twice a day, for 3 days, in two doses: O1-0.57 mg/kg body weight (b.w.), O2-5.71 mg/kg b.w. Twelve hours after the last injection half of the animals were terminated (I). The remaining rats were kept for the next 6 weeks without any xenobiotics (II). The blood was taken from the still beating heart and then centrifuged. The plasma level of MDA was determined and compared to the 1 mg of the blood protein.
A significant (p < 0.05) increase of MDA level was found in the O2II group, as compared with the O2I group. The level of MDA was higher after 6 weeks' period in relation to the animals that were terminated on the 4th day of the experiment.
Three-day omeprazole administration did not change the MDA level in the rat plasma.
奥美拉唑是一种质子泵抑制剂，在不同胃肠疾病的治疗中应用日益广泛。本研究的目的是评估奥美拉唑（O）对血浆丙二醛（MDA）水平的影响。
对雄性Wistar大鼠腹腔注射奥美拉唑，每天两次，持续3天，分两种剂量：O1-0.57毫克/千克体重（b.w.），O2-5.71毫克/千克b.w.。最后一次注射12小时后，将一半动物处死（I）。其余大鼠在接下来的6周内不给予任何外源化合物（II）。从仍在跳动的心脏取血，然后离心。测定血浆MDA水平，并与1毫克血液蛋白进行比较。
与O2I组相比，O2II组MDA水平显著升高（p<0.05）。与在实验第4天处死的动物相比，6周后MDA水平更高。
连续3天给予奥美拉唑未改变大鼠血浆中MDA水平。
