Ladabaum U, Brown M B, Pan W, Owyang C, Hasler W L
Division of Gastroenterology, Department of Internal Medicine, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109-0362, USA.
Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G201-8. doi: 10.1152/ajpgi.2001.280.2.G201.
Distal gastric distension may contribute to meal-related dyspeptic symptoms. This study's aims were to determine the effects of distinct nutrient classes on symptoms induced by distal gastric distension and their dependence on 5-hydroxytryptamine(3) (5-HT3) receptors. Nine healthy subjects rated pain, nausea, and bloating induced by isobaric distal gastric distensions (6-24 mmHg) during duodenal lipid, carbohydrate, protein, or saline perfusion after treatment with placebo or the 5-HT3 receptor antagonist granisetron (10 microg/kg iv). Distensions produced greater pain, nausea, and bloating with lipid at 1.5 kcal/min compared with saline (P < or = 0.02), primarily because of greater distal gastric volumes at each distending pressure. In contrast, carbohydrate and protein had no significant effect. At 3 kcal/min, lipid increased symptoms through a volume-independent as well as a volume-dependent effect. Granisetron did not affect symptom perception or gastric pressure-volume relationships. In conclusion, isobaric distal gastric distension produces more intense symptoms during duodenal lipid compared with saline perfusion. Symptom perception during distal gastric distension is unaffected by 5-HT3 receptor antagonism.
胃远端扩张可能导致与进餐相关的消化不良症状。本研究的目的是确定不同营养物质类别对胃远端扩张诱发症状的影响及其对5-羟色胺(3)(5-HT3)受体的依赖性。9名健康受试者在十二指肠灌注脂质、碳水化合物、蛋白质或生理盐水后，用安慰剂或5-HT3受体拮抗剂格拉司琼(10μg/kg静脉注射)治疗，对等压胃远端扩张(6-24 mmHg)诱发的疼痛、恶心和腹胀进行评分。与生理盐水相比，在1.5千卡/分钟的脂质灌注时，扩张产生的疼痛、恶心和腹胀更严重(P≤0.02)，这主要是因为在每个扩张压力下胃远端容积更大。相比之下，碳水化合物和蛋白质没有显著影响。在3千卡/分钟时，脂质通过与容积无关以及与容积相关的效应增加症状。格拉司琼不影响症状感知或胃压力-容积关系。总之，与生理盐水灌注相比，十二指肠脂质灌注期间等压胃远端扩张产生更强烈的症状。胃远端扩张期间的症状感知不受5-HT3受体拮抗作用的影响。
