Goodrick C L
J Gerontol. 1975 May;30(3):257-63. doi: 10.1093/geronj/30.3.257.
Measures of life-span were obtained for male and female A/J, BALB/cJ, C57BL/6J, and DBA/2J inbred mouse strains and the six possible hybrid combinations (N equals 500, 10 groups, 25 male and 25 female per group). C57BL/6J mice were long lived, while A/J, BALB/cJ and DBA/2J mice were short lived, with the exception of female BALB/cJ mice, which lived as long as C57BL/6J mice. Female BALB/cJ and two female hybrid mouse groups with a BALB/cJ parent lived longer than males, but significant sex differences were not obtained for other groups. In general, the mode of inheritance of longevity was overdominant. For a second study (N equals 400) of the longevity of A/J and C57BL/6J strains and F1 and F2 hybrids it was estimated that one genetic factor was associated with longevity and the coefficient of genetic determination for longevity was estimated as between .48 and .79.
我们获取了雄性和雌性A/J、BALB/cJ、C57BL/6J和DBA/2J近交系小鼠的寿命数据，以及六种可能的杂交组合（N = 500，共10组，每组25只雄性和25只雌性）。C57BL/6J小鼠寿命较长，而A/J、BALB/cJ和DBA/2J小鼠寿命较短，但雌性BALB/cJ小鼠除外，其寿命与C57BL/6J小鼠相同。雌性BALB/cJ小鼠以及有BALB/cJ亲本的两个雌性杂交小鼠组比雄性寿命长，但其他组未观察到显著的性别差异。总体而言，长寿的遗传模式是超显性的。在第二项研究中（N = 400），对A/J和C57BL/6J品系以及F1和F2杂交种的寿命进行研究，估计有一个遗传因素与长寿相关，长寿的遗传决定系数估计在0.48至0.79之间。
