免疫组织化学检测患有神经皮肤黑素沉着症婴儿先天性黑素细胞痣中的c-met原癌基因产物。
Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis.
作者信息
Takayama H, Nagashima Y, Hara M, Takagi H, Mori M, Merlino G, Nakazato Y
机构信息
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
出版信息
J Am Acad Dermatol. 2001 Mar;44(3):538-40. doi: 10.1067/mjd.2001.112403.
Transgenic mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF) demonstrate extensive pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous melanosis, indicating that deregulation of HGF/SF-Met signaling in the critical period of development may lead to this fatal syndrome.
过表达肝细胞生长因子/分散因子（HGF/SF）的转基因小鼠在皮肤和中枢神经系统的软脑膜中均表现出广泛的色素痣，类似于人类神经皮肤黑素沉着症。我们通过免疫组织化学方法在一名患有神经皮肤黑素沉着症的婴儿的先天性痣中检测到了HGF/SF受体Met，这表明在发育的关键时期HGF/SF-Met信号通路失调可能导致这种致命综合征。
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