Hock D L, Sharafi K, Dagostino L, Kemmann E, Seifer D B
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
J Reprod Med. 2001 Jan;46(1):7-10.
To determine if ovarian reserve, as measured by day 3 levels of E2 and FSH, was different in patients with endometriosis as compared to controls.
Case-control study of 75 women with laparoscopically staged endometriosis and 75 age-matched controls undergoing in vitro fertilization/embryo transfer for male factor infertility.
In women with stage III/IV endometriosis (revised American Fertility Society staging), day 3 E2 and FSH levels were significantly higher than control levels (51.9 pg/mL and 12.6 mIU/mL versus 34.7 pg/mL and 9.7 mIU/mL, P < .03). In contrast, women with stage I/II endometriosis did not differ significantly when compared to controls (36.8 pg/mL and 10.4 mIU/mL versus 34.0 pg/mL and 10.2 mIU/mL). The total group showed significantly higher E2 levels (41.8 pg/mL versus 34.1 pg/mL, P < .03), but no significant differences in FSH levels were observed.
These data show that women with stage III/IV endometriosis have relatively diminished ovarian reserve, while this situation is not noted in women with stage I/II endometriosis. This observation is consistent with progressive loss of ovarian reserve in women with increasing stages of endometriosis independent of age.
通过检测第3天的雌二醇（E2）和促卵泡生成素（FSH）水平来确定子宫内膜异位症患者与对照组相比，其卵巢储备功能是否存在差异。
对75例经腹腔镜分期的子宫内膜异位症女性患者和75例因男性因素不育而接受体外受精/胚胎移植的年龄匹配的对照组进行病例对照研究。
在III/IV期子宫内膜异位症（美国生殖医学协会修订分期）患者中，第3天的E2和FSH水平显著高于对照组（分别为51.9 pg/mL和12.6 mIU/mL，对照组为34.7 pg/mL和9.7 mIU/mL，P < 0.03）。相比之下，I/II期子宫内膜异位症患者与对照组相比无显著差异（分别为36.8 pg/mL和10.4 mIU/mL，对照组为34.0 pg/mL和10.2 mIU/mL）。总体组显示E2水平显著更高（41.8 pg/mL对34.1 pg/mL，P < 0.03），但FSH水平未观察到显著差异。
这些数据表明，III/IV期子宫内膜异位症患者的卵巢储备功能相对降低，而I/II期子宫内膜异位症患者未观察到这种情况。这一观察结果与子宫内膜异位症分期增加的女性中卵巢储备功能的逐渐丧失一致，且与年龄无关。
