Remy D C, Van Saun W A, Engelhardt E L
J Med Chem. 1975 Feb;18(2):142-8. doi: 10.1021/jm00236a006.
The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.
描述了一系列2-、3-和4-取代苄胺衍生物的合成。研究了这些化合物对实验性心律失常的影响。许多衍生物，特别是2-(对甲氧基苯乙炔基)苄胺(3d)、α,α-二甲基-4-(苯乙炔基)苄胺(7a)和α,α-二甲基-4-苯乙苄胺(12g)，显示出良好的抗心律失常活性。
