Portolani M, Pecorari M, Pietrosemoli P, Bartoletti A, Sabbatini A M, Meacci M, Gennari W, Bazzani E, Beretti F, Guaraldi G
Department of Hygiene, Microbiology and Biostatistics, Center for Diagnosis of Viral Diseases.
New Microbiol. 2001 Jan;24(1):11-5.
Twenty five cases of meningitis occurred in urban areas surrounding a city (Modena) in Northern Italy, in the period May-July 1999. When the patients were admitted to the Infectious Diseases Division of the University of Modena and Reggio Emilia Hospital and studied by virological and serological methods, the meningitis proved to have an enteroviral origin and enterovirus ECHO 4 type was responsible for all cases of illness. An epidemiological characteristic of the enteroviral meninigitis outbreak was the adult age in 23 out of the 25 patients (mean age 24.50 +/- 7.84 years). The monthly distribution of the aseptic meningitis cases was the following: five cases occurred in May, 13 in June and seven in July. The origin of the spread of the virus infection and the reason for its sudden end remained unknown. The unusual drop in temperature which occurred in the geographic area involved in the aseptic meningitis outbreak at the beginning of August could have interfered with the slowdown in virus circulation.
1999年5月至7月期间，意大利北部一座城市（摩德纳）周边的市区发生了25例脑膜炎病例。当这些患者被送往摩德纳和雷焦艾米利亚大学医院的传染病科，并通过病毒学和血清学方法进行研究时，发现脑膜炎源于肠道病毒，所有病例均由肠道病毒埃可4型引起。此次肠道病毒性脑膜炎暴发的一个流行病学特征是，25名患者中有23名是成年人（平均年龄24.50 +/- 7.84岁）。无菌性脑膜炎病例的月度分布情况如下：5例发生在5月，13例在6月，7例在7月。病毒感染传播的源头以及其突然终止的原因仍然不明。8月初，无菌性脑膜炎暴发所涉及的地理区域出现了异常降温，这可能对病毒传播的减缓起到了干扰作用。
