狐衣酸作为潜在的抗炎剂。1. 芳环上带有取代基的狐衣酸。
Vulpinic acids as potential antiinflammatory agents. 1. Vulpinic acids with substituents in the aromatic rings.
作者信息
Foden F R, McCormick J, O'Mant D M
出版信息
J Med Chem. 1975 Feb;18(2):199-203. doi: 10.1021/jm00236a020.
PMID:1120988
Abstract
The preparation of a series of vulpinic acids, substituted in either or both of the aromatic rings, is described. The compounds were found to be active in the adjuvant arthritis test in rats. High activity combined with an acceptable therapeutic ratio was confined to analogs with electron-withdrawing substituents in the meta positions of the rings.
摘要
本文描述了一系列在一个或两个芳香环上有取代基的狐衣酸的制备方法。这些化合物在大鼠佐剂性关节炎试验中被发现具有活性。高活性与可接受的治疗指数相结合的情况仅限于在环的间位带有吸电子取代基的类似物。
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