Linear regression analysis of inhibitory potency of organic disulfides against Histoplasma capsulatum.
作者信息
Schaad L J, Werner R H, Dillon L, Field L, Tate C E
出版信息
J Med Chem. 1975 Apr;18(4):344-51. doi: 10.1021/jm00238a004.
PMID:1121000
Abstract
The Free-Wilson equations are derived for the case of symmetrical substitution and are applied, in four modifications, to in vitro inhibitory activity of 77 organic disulfides against Histoplasma capsulatum. Substituent constants are listed to aid in the design of new inhibitory agents against this human pathogen (and perhaps other fungal organisms).
摘要
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Linear regression analysis of inhibitory potency of organic disulfides against Histoplasma capsulatum.
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