环烷酮。6. 2,8-二苄基环辛酮衍生物中降胆固醇活性与抗生育活性的分离
Cycloalkanones. 6. Separation of hypocholesterolemic and antifertility activities in derivatives of 2,8-dibenzylcyclooctanone.
作者信息
Carlson G L, Hall I H, Piantadosi C
出版信息
J Med Chem. 1975 Apr;18(4):432-4. doi: 10.1021/jm00238a023.
PMID:1121011
Abstract
Fluoro and hydroxy derivatives of 2,8-dibenzylcyclooctanone were prepared. Separation of antifertility activity from hypolipidemic and uterotropic effects was achieved with 2,8-bis(4-acetoxybenzyl)cyclooctanone. Some enhancement of the hypolipidemic effect in relation to the uterotropic and antifertility activities was seen in 2,8-bis(4-fluorobenzyl)cyclooctanone. Synthetic methods for the hydroxy compounds are presented.
摘要
制备了2,8-二苄基环辛酮的氟代和羟基衍生物。2,8-双(4-乙酰氧基苄基)环辛酮实现了抗生育活性与降血脂和子宫促生长作用的分离。在2,8-双(4-氟苄基)环辛酮中，观察到降血脂作用相对于子宫促生长和抗生育活性有一定增强。介绍了羟基化合物的合成方法。
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