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[胚胎神经组织移植对大鼠脊神经背根再生的影响]

[Effect of embryonal nerve tissue transplantation on regeneration of dorsal roots of the rat spinal nerves].

作者信息

Khrenov A P, Novikov L N, Novikova L N

机构信息

Department of Histology, State Medical Academy of Nizhny Novgorod.

出版信息

Morfologiia. 2000;118(6):40-4.

Abstract

Using cobalt salts axonal ionophoresis posttraumatic regeneration of TXII dorsal roots nerve fibres in the zone of hemisection in conditions of 14 wks embryo spinal cord transplantation into the zone of trauma of spinal cord. Regro Invasion of dorsal roots nerve fibres into recipients posterior cords and Lissawers tract through the transitional zone "spinal cord--dorsal roots" was observed on posttransplantation d 14-120. It was show that afferent axons predominantly spread in substantia alba and substantia grisea caudal to the level of spinal cord transection with only individual fibres invading rostrad through the neuronal plate. In the transplants neurons were encountered up to d 120 of the observation although transplant neuropil was limited from recipient tissue brain by a glial and connective tissue scar. The influence of embryonal nervous tissue transplantation on intraspinal regeneration of dorsal roots afferents was discussed.

摘要

在将14周龄胚胎脊髓移植到脊髓创伤区域的条件下,使用钴盐进行轴突离子导入,观察脊髓半切区域TXII背根神经纤维的创伤后再生。移植后第14 - 120天,观察到背根神经纤维通过“脊髓 - 背根”过渡区侵入受体后索和利氏束。结果表明,传入轴突主要在脊髓横断水平尾侧的白质和灰质中扩散,只有个别纤维通过神经板向头侧侵入。在观察到第120天时,在移植组织中仍可发现神经元,尽管移植的神经毡被胶质和结缔组织瘢痕与受体组织脑分隔开。讨论了胚胎神经组织移植对脊髓内背根传入纤维再生的影响。

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