Brewer D W
Laryngoscope. 1975 Mar;85(3):499-515. doi: 10.1288/00005537-197503000-00007.
A compilation of late and early symptoms of patients who ultimately were found to have laryngeal disease was carried out. Notation of even minor changes in the indirect laryngoscopic appearance of the same patients was made routinely. Correlation of symptoms with signs has made possible a better understanding of the natural history of certain laryngeal lesions such as contact ulcer, polyps, nodes, dysphonia plica ventricularis as well as some of the pareses, paralyses and fixations. Identical early symptoms and numerous signs have apparently been ignored in subsequently proven cases of cancer of the larynx. The expanded list of symptoms (33 in number) and the detailed list of signs (54 in number) may now assist the Otolaryngologist in earlier diagnosis. Although the reported findings are not specifically diagnostic of cancer of the larynx, they should draw earlier attention to the larynx as the etiological site of such symptoms. Earlier recognition of minor laryngeal changes, as detailed in the text, should lead to earlier biopsy and tissue diagnosis, earlier and more enlightened public awareness, and earlier and, therefore, more effective utilization of present day day modalities in the management of carcinoma of the larynx.
对最终被确诊患有喉部疾病的患者的晚期和早期症状进行了汇总。对同一患者间接喉镜检查外观上哪怕是微小的变化都进行了常规记录。症状与体征的关联使得人们能够更好地了解某些喉部病变的自然史，如接触性溃疡、息肉、结节、室带性发音障碍以及一些麻痹、瘫痪和固定情况。在随后确诊的喉癌病例中，相同的早期症状和众多体征显然被忽视了。现在，扩充后的症状清单（共33项）和详细的体征清单（共54项）可能有助于耳鼻喉科医生进行更早的诊断。虽然所报告的发现并非喉癌的特异性诊断依据，但它们应能使人们更早地将喉部视为这些症状的病因部位而加以关注。如文中详细所述，更早地识别喉部的微小变化应能带来更早的活检和组织诊断、更早且更具启发性的公众意识，以及在喉癌治疗中更早且因此更有效地利用当今的治疗手段。
