Bataille D, Héron L, Virsolvy A, Peyrollier K, LeCam A, Gros L, Blache P
Institut National de la Santé et de la Recherche Médicale U376, CHU Arnaud-de-Villeneuve, Montpellier, France.
Cell Mol Life Sci. 1999 Oct 1;56(1-2):78-84. doi: 10.1007/s000180050008.
ATP-dependent potassium (K ATP) channels occupy a key position in the control of insulin release from the pancreatic beta cell since they couple cell polarity to metabolism. These channels close when more ATP is produced via glucose metabolism. They are also controlled by sulfonylureas, a class of drugs used in type 2 diabetic patients for triggering insulin secretion from beta cells that have lost part of their sensitivity to glucose. We have demonstrated the existence of endogenous counterparts to sulfonylureas which we have called 'endosulfines.' In this review, we describe the discovery, isolation, cloning, and biological features of the high-molecular-mass form, alpha-endosulfine, and discuss its possible role in the physiology of the beta cell as well as in pathology.
ATP 依赖性钾（KATP）通道在胰腺β细胞胰岛素释放的控制中占据关键地位，因为它们将细胞极性与代谢联系起来。当通过葡萄糖代谢产生更多 ATP 时，这些通道会关闭。它们也受磺脲类药物控制，磺脲类药物是用于 2 型糖尿病患者的一类药物，用于触发已失去部分葡萄糖敏感性的β细胞分泌胰岛素。我们已经证明存在磺脲类药物的内源性对应物，我们将其称为“内磺素”。在这篇综述中，我们描述了高分子量形式α-内磺素的发现、分离、克隆和生物学特性，并讨论了其在β细胞生理学以及病理学中的可能作用。
