Takahashi S, Kakinuma N, Iwai H, Yanagisawa T, Nagai K, Suzuki K, Tokunaga T, Nakagawa A
Department of Biosciences, Teikyo University, Utsunomiya, Japan.
J Antibiot (Tokyo). 2000 Nov;53(11):1252-6. doi: 10.7164/antibiotics.53.1252.
Three novel quinolone compounds, quinolactacins A (1), B (2) and C (3), have been found from the fermentation broth of Penicillium sp. EPF-6, a fungus isolated from the larvae of mulberry pyralid (Margaronia pyloalis Welker). The molecular formulas of 1, 2 and 3 were determined to be C16H18N2O2, C15H16N2O2 and C16H18N2O3, respectively by FAB-MS and NMR spectral analyses. The structures of these compounds have a novel quinolone skeleton with a gamma-lactam ring consisting of C12H8N2O2 as the common chromophore.
从桑螟（Margaronia pyloalis Welker）幼虫分离出的真菌青霉菌株EPF-6的发酵液中发现了三种新型喹诺酮化合物，即喹诺拉克汀A（1）、B（2）和C（3）。通过快原子轰击质谱（FAB-MS）和核磁共振光谱（NMR）分析，确定1、2和3的分子式分别为C16H18N2O2、C15H16N2O2和C16H18N2O3。这些化合物的结构具有一个新型喹诺酮骨架，其γ-内酰胺环由C12H8N2O2作为共同发色团组成。
