Matsuyama S, Shimokawa K, Yokoki Y
Natl Inst Anim Health Q (Tokyo). 1975 Spring;15(1):38-44.
Small quantities of diethylstilbestrol and testosterone proprionate were implanted into the hypothalamic arcuate nucleus of male rats of the Wistar-Imamichi strain at 43 days of age. The animals were sacrificed at 64 or 76 days of age. Diethylstilbestrol suppressed the development of all genital organs and disturbed spermatogenesis. The damage was found to have recovered slightly in rats sacrificed at 76 days of age. Testosterone propionate was also effective for the atrophy of some genital organs. Its influence was not so severe as that of diethylstilbestrol. It extinguished almost completely 33 days after implantation. On the contrary, the numbers of spermatogonia and spermatocytes per cross section of the seminiferous tubule were smaller at 76 days than at 64 days of age. The diameter of the seminiferous tubule in the rat implanted with testosterone propionate was longer at 76 days than at 64 days of age. Therefore, the tubular diameter did not always represent the quantity or quality of spermatogenesis. The results also suggested that spermatogenesis might have been disturbed in some of the rats in which androgen was considered to be secreted almost normally.
将少量己烯雌酚和丙酸睾酮植入43日龄的Wistar-Imamichi品系雄性大鼠的下丘脑弓状核。在64或76日龄时处死动物。己烯雌酚抑制了所有生殖器官的发育并干扰了精子发生。发现在76日龄处死的大鼠中损伤稍有恢复。丙酸睾酮对某些生殖器官的萎缩也有效。其影响不如己烯雌酚严重。植入后33天其影响几乎完全消失。相反，76日龄时曲细精管每横截面积的精原细胞和精母细胞数量比64日龄时少。植入丙酸睾酮的大鼠在76日龄时曲细精管直径比64日龄时更长。因此，管直径并不总是代表精子发生的数量或质量。结果还表明，在一些被认为雄激素分泌几乎正常的大鼠中，精子发生可能受到了干扰。
