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[用于评估不同强度辐射影响的微核和染色体畸变试验可能性的比较]

[Comparison of the possibilities of micronuclear and chromosomal aberration tests for evaluation of the effects of radiation of different intensities].

作者信息

Shemetun G M, Pilins'ka M A, Ieremieieva M M

出版信息

Tsitol Genet. 2000 Sep-Oct;34(5):3-10.

Abstract

The comparative evaluation of sensitivity and specificity of the micronucleus and chromosome aberration tests for human lymphocytes at the delayed terms after acute exposure to high-dose as well as during constant exposure to low-dose gamma-radiation has been done. Accordance between these tests registered only in the cases of acute radiation sickness of second and third degrees of severity (irradiation doses above 200 cGy). Unspecificity of micronucleus test for estimation of the radiation load under constant low-intensity irradiation was found.

摘要

已经对急性高剂量照射后延迟期以及持续低剂量γ射线照射期间人类淋巴细胞的微核和染色体畸变试验的敏感性和特异性进行了比较评估。仅在严重程度为二度和三度的急性放射病(照射剂量高于200 cGy)病例中,这些试验之间呈现出一致性。研究发现,在持续低强度照射下,微核试验在评估辐射负荷方面存在非特异性。

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