Siimes M A, Koerper M A, Licko V, Dallman P R
Pediatr Res. 1975 Mar;9(3):127-9. doi: 10.1203/00006450-197503000-00003.
The concentration of plasma ferritin was measured in serial samples of blood removed from six preterm neonates undergoing exchange transfusion for hyperbilirubinemia. The average plasma ferritin concentration in the infants was 218 ng/ml compared with 47 ng/ml in the donors. The mean concentration of ferritin decreased an average of 62 ng/ml during the exchange transfusions. The plasma ferritin half-life was computed to be 2.5 and 5.5 min in the two infants weighing 2,000 and 2,500 g compared with a half-life of 4 min in the rat. In four infants weighing between 1,000 and 1,180 g, the half-life ranged from 9.1 to 34 min. These data support the concept of a rapid plasma ferritin turnover and indicate that ferritin may transport a large amount of iron through the plasma compartment in spite of its low concentration.
对六名因高胆红素血症接受换血治疗的早产儿采集系列血样，测定血浆铁蛋白浓度。婴儿的平均血浆铁蛋白浓度为218 ng/ml，而供血者为47 ng/ml。换血期间铁蛋白平均浓度下降了62 ng/ml。两名体重分别为2000克和2500克的婴儿，其血浆铁蛋白半衰期经计算分别为2.5分钟和5.5分钟，而大鼠的半衰期为4分钟。在四名体重在1000至1180克之间的婴儿中，半衰期为9.1至34分钟。这些数据支持血浆铁蛋白快速周转的概念，并表明尽管铁蛋白浓度较低，但它可能通过血浆室转运大量铁。
